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Tizanidine
Clinical data
Pronunciation/ t aɪ ˈ z æ n ɪ d iː n / tye- ZAN -i-deen
Trade namesZanaflex, Sirdalud, and others
AHFS/Drugs.comMonograph
MedlinePlusa601121
Pregnancy categoryC
Routes of administrationBy mouth (tablets, capsules)
ATC codeM03BX02 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~40% [1]
Protein binding~30%
MetabolismLiver (CYP1A2, 95%)
Elimination half-life2.54 hours (tizanidine), 20–40 hours (inactive metabolites) [1]
ExcretionUrine (60%), feces (20%)

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Edation Tizanidine can cause dizziness and drowsiness.alk to your doctor or pharmacist if you have any questions or concerns. Highly clinically significant.

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The influence of hepatic impairment on the pharmacokinetics of tizanidine has not been evaluated. Because tizanidine is extensively metabolized in the liver, hepatic impairment would be expected zanaflex 10 mg have significant effects on pharmacokinetics of tizanidine.When my doctor suggested this medicine to me I made sure that it was not a narcotic and habit forming.

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It is important to emphasize that, although the events reported occurred during treatment with tizanidine, they were not necessarily caused by it.For comparison purposes, the corresponding frequency of the event per 100 patients among placebo treated patients is also provided.

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