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Prescribing PPIs to infants is another off-label use.The intravenous injection of esomeprazole should be administered over at least 3 minutes. The intravenous infusion should be administered over 10 to 30 minutes.

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When using NEXIUM consider alternative anti-platelet therapy Daily treatment with any acid-suppressing medications over a long period of time eg, longer than 3 years may lead to malabsorption of cyanocobalamin vitamin B12 Rare reports of cyanocobalamin deficiency occurring with acid-suppressing therapy have been reported in the literature Hypomagnesemia has been reported rarely with prolonged treatment with PPI nexium bone pain and may require decrease esomeprazole nexium bones pain.

Avoid concomitant use of NEXIUM nexium bone pain St. John's wort or Literature suggests that concomitant use of PPIs with methotrexate primarily at high dose; see methotrexate prescribing information may elevate and prolong serum levels of methotrexate and/or its metabolite, possibly leading to methotrexate toxicities.Omeprazole is widely used as a proton pump inhibitor PPI for treating and preventing acid related diseases in human and veterinary medicine, and it is administered as a racemic mixture of 2 optical isomers: S omeprazole esomeprazole and R omeprazole.

2 These 2 enantiomers are converted in the same proportions to an achiral active form in the acidic compartment of gastric parietal cells.

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