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A fertility study in rats at doses up to 300 mg per kg per day revealed no evidence of impaired fertility. The efficacy of bupropion hydrochloride tablets in the treatment of major depressive disorder was established in two 4-week, placebo-controlled trials in adult inpatients with MDD Trials 1 and 2 in Table 4 and in one 6-week, placebo-controlled wellbutrin sr review weight loss in adult outpatients with MDD Trial 3 in Table 4 In the first trial, the dose range of bupropion hydrochloride wellbutrin sr reviews weight loss was 300 mg to 600 mg per day administered in 3 divided doses; 78% of subjects were treated with doses of 300 mg to 450 mg per day.First, they were looking for a certain result, and unsurprisingly, they found it.
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Avoiding bedtime administration of the evening dose of bupropion may lessen the occurrence of insomnia commonly experienced during initiation of bupropion therapy Short-term administration of an intermediate- to long-acting sedative hypnotic also may be useful during the first week of therapy but thereafter generally is not needed.
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