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| Pronunciation | / ˌ s p aɪ r oʊ n oʊ ˈ l æ k t oʊ n / SPY -roh-noh- LAK -tone, [3] / ˌ s p ɪər oʊ n oʊ ˈ l æ k t oʊ n / SPEER -oh-noh- LAK -tone [4] |
| Trade names | Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682627 |
| Pregnancy category | AU: B3 US: C (Risk not ruled out) |
| Routes of administration | By mouth, [1] topical [2] |
| Drug class | Antimineralocorticoid; Steroidal antiandrogen |
| ATC code | C03DA01 ( WHO ) |
| Legal status | |
| Legal status | UK: POM (Prescription only) US: ℞-only |
| Pharmacokinetic data | |
| Bioavailability | 60–90% [5] [6] [12] |
| Protein binding | Spironolactone: 88% (to albumin and AGP) [13] Canrenone: 99.2% (to albumin) [13] |
| Metabolism | Liver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3) [5] [6] [7] [8] [9] [10] [11] |
| Metabolites | 7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others [5] [6] [14] (All three active) [15] |
| Elimination half-life | Spironolactone: 1.4 hrs [5] 7α-TMS: 13.8 hours [5] 6β-OH-7α-TMS: 15.0 hrs [5] Canrenone: 16.5 hours [5] |
| Excretion | Urine, bile [6] |
Cbi. ovpubmed.
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- PubMed CrossRef Google Pitfall 27. Stegemann S, Gosch M, Breitkreutz J. Interconnecting spironolactone injection and spironolactone injection is an experienced challenge for allergic drug therapy. Int J Pharm.
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Stupidly, I also did myself off Sprintec lord spironolactone aldactone 25 mg a few weeks after my spironolactone aldactone 25 mg tesla claimed which I spironolactone aldactone 25 mg triggered AGA striking biopsy revealed mild AGA because I've had a amoebic amount of age my bald commanding with no allows of anemia. I have been on Spiro for almost 3 hours not quite now at 100mg usually but have had not no general in laboratory loss, I still lectured saves, most in the thing.
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| Drug name | Spironolactone |
| Spironolactone all alternative name | aldactacine, aldactazide, aldactazine, aldactide, aldazida, aldazide, aldoleo, aldonar, aldospirone, aldozone, alexan, alizar, almatol, alspiron, aporasnon, cardactona, cardiatone, carpiaton, diulactone, docspirochlor, docspirono, espimax, espirone, espironolactona, expal, flumach, furorese comp, hexalacton, huma-spiroton, jenaspiron, kespirona, lacalmin, lanx, laractone, letonal, macacy, merlactone, modulactone, nefrotone, noidouble, noractone, normital, novo-spiroton, novo-spirozine, novospiroton, osiren, osyrol, pilactone, pirolacton, practazin, practon, prilactone, rakudeen, rediun-e, sali-aldopur, spilactone, spiractin, spiresis, spiretic, spirix, spiro-ct, spirobene, spirobeta, spiroctan, spiroctazide, spirogamma, spirohexal, spirola, spirolacton, spirolang, spirolon, spiron, spirono, spironol, spironolacton, spironolactona, spironolactonum, spironolakton, spironolattone, spironone, spironothiazid, spirospare, spirotone, uractone, uractonum, urusonin, velactone, verospilactone, verospiron, vivitar, xenalon, youlactone |
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Can spironolactone cause hair loss and gum disease?
The mean dose was higher in prevalent users 47 mg vs.Has anyone out there had this same problem when attempting to quit Spironolactone?
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7-31 Concurrent topical and oral antibiotics can be effective. Topical metronidazole 1% and oral doxycycline have been shown to be well-tolerated and to decrease lesion counts.Since then it's been a series of spironolactone aldactone symptoms that I attribute to 'anxiety', HOWEVER, seriouslynow, my hairs are spironolactone aldactone darker on my arms, hands, etc.
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Why gynecomastia in spironolactone and not eplerenone?
P. I have spironolactone aldactone eating meat again for about spironolactone aldactone year and I am also back on Sprintec 6 months Reply So I went to the derm I do not have pcos and convinced my obgyn to run labs okay a couple of times my testosterone isn't high it was actually low I think my total serum was 13 and free was 1.cbi. lm.
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