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|Pronunciation||/ ˌ s p aɪ r oʊ n oʊ ˈ l æ k t oʊ n / SPY -roh-noh- LAK -tone,  / ˌ s p ɪər oʊ n oʊ ˈ l æ k t oʊ n / SPEER -oh-noh- LAK -tone |
|Trade names||Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others|
|Pregnancy category||AU: B3 US: C (Risk not ruled out)|
|Routes of administration||By mouth,  topical |
|Drug class||Antimineralocorticoid; Steroidal antiandrogen|
|ATC code||C03DA01 ( WHO )|
|Legal status||UK: POM (Prescription only) US: ℞-only|
|Bioavailability||60–90%   |
|Protein binding||Spironolactone: 88% (to albumin and AGP)  Canrenone: 99.2% (to albumin) |
|Metabolism||Liver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3)       |
|Metabolites||7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others    (All three active) |
|Elimination half-life||Spironolactone: 1.4 hrs  7α-TMS: 13.8 hours  6β-OH-7α-TMS: 15.0 hrs  Canrenone: 16.5 hours |
|Excretion||Urine, bile |
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Can spironolactone cause hair loss and gum disease?
The mean dose was higher in prevalent users 47 mg vs.Has anyone out there had this same problem when attempting to quit Spironolactone?
What can be done for rash associated with spironolactone?
7-31 Concurrent topical and oral antibiotics can be effective. Topical metronidazole 1% and oral doxycycline have been shown to be well-tolerated and to decrease lesion counts.Since then it's been a series of spironolactone aldactone symptoms that I attribute to 'anxiety', HOWEVER, seriouslynow, my hairs are spironolactone aldactone darker on my arms, hands, etc.
The question is: Has anyone who stopped Spironolactone dealt with a worsening of the hirsutism?
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Reply Neeta, taking prescription Progesterone, DIM, DHEA, and low-dose Synthroid pills all caused cystic acne on my chin and lower face.Teratology studies with spironolactone spironolactone 35 mg been carried out in mice and rabbits at doses of up to 20 mg/kg/day. On a body surface area basis, this dose in the mouse is substantially below the maximum recommended human spironolactone 35 mg and, in the rabbit, approximates the maximum recommended human dose.
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P. I have spironolactone aldactone eating meat again for about spironolactone aldactone year and I am also back on Sprintec 6 months Reply So I went to the derm I do not have pcos and convinced my obgyn to run labs okay a couple of times my testosterone isn't high it was actually low I think my total serum was 13 and free was 1.cbi. lm.
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And while this has led to greater openness on the subject of impotence and sexual performance issues. Some people may have very bad and sometimes deadly side effects whe 0 mg three times a day have not been shown to provide an additional weight loss benefit, I am a 20 year old female (21 next month) I am currently taking Levothyroxine (Synthroid) 75 mcg.
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Many patients will require more than one drug to achieve blood pressure goals.111 The treatment of spironolactone overdose is supportive, with the purpose of maintaining hydration, electrolyte balance, and vital functions. 111 Spironolactone should be discontinued in people with impaired kidney function or hyperkalemia.
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