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1997. • Levetiracetam. Keppra. 1999. • Oxcarbazepine. Trileptal. 2000. • Zonisamide. Zonegran. 2000. • Pregabalin . Lyrica. 2005. • Lacosamide.

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DOI. PubMed CrossRef Google Scholar NCT. A pregabalin doe blind, pregabalin doe controlled cross over study in fibromyalgia subjects to examine effects of pregabalin on brain response to mechanical pain as assessed by functional magnetic resonance imaging, proton magnetic resonance spectroscopy and subjective ratings.Am J Health Syst Pharm.

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2009.Lyrica is indicated for the treatment of peripheral and central neuropathic pain in adults.

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In a case-control study of opioid users, those patients who took pregabalin concomitantly with an opioid had an increased risk for opioid-related death compared to opioid use alone adjusted odds ratioaOR.

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PubMed CrossRef Google Scholar 58. Crociolli GC, Cassu RN, Barbero RC, Rocha TL, Gomes DR, Nicacio GM. Gabapentin as an pregabalin doe for postoperative pain management in dogs undergoing mastectomy.In this study, when compared to patients not exposed to preoperative gabapentin, the risk of respiratory depression was increased 60 percent for patients using regional anesthesia odds ratioOR. onfidence intervalCI.

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