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21 January 2009. Archived from the original on 27 January 2009.12 13 Levothyroxine: Orlistat can bind with levothyroxine in the gut and reduce its absorption leading to a decrease in plasma concentration of levothyroxine and subsequent hypothyroidism. Thus, clinicians should advise patients to take levothyroxine and orlistat at least 4 hours apart.
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