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Clinical data | |
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Pronunciation | Paracetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen ) |
Trade names | Tylenol, Panadol, others [2] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a681004 |
License data | US FDA: Acetaminophen |
Pregnancy category | AU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe |
Routes of administration | By mouth, through the cheek, rectal, intravenous (IV) |
ATC code | N02BE01 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC |
Pharmacokinetic data | |
Bioavailability | 63–89% [4] : 73 |
Protein binding | 10–25% [5] |
Metabolism | Predominantly in the liver [3] |
Metabolites | APAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6] |
Onset of action | Pain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7] |
Elimination half-life | 1–4 hours [3] |
Excretion | Urine (85–90%) [3] |
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A patient history is very important for diagnosis.There was no evidence to evaluate the effectiveness of non-medicated lozenges, sprays or mouthwashes. Corticosteroids were found to reduce the duration of pain by about 14 to 48 hours, but there was no benefit in terms of how long people were off work or school, or whether their symptoms recurred.
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