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| Clinical data | |
|---|---|
| Trade names | Apo-hydro, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682571 |
| License data | EU EMA: by INN |
| Pregnancy category | B (D if used to treat pregnancy-induced hypertension) |
| Routes of administration | Oral (capsules, tablets, oral solution) |
| ATC code | C03AA03 ( WHO ) |
| Legal status | |
| Legal status | In general: ℞ (Prescription only) |
| Pharmacokinetic data | |
| Bioavailability | Variable (~70% on average) |
| Metabolism | Not significant [1] |
| Elimination half-life | 5.6–14.8 h |
| Excretion | Primarily kidney (>95% as unchanged drug) |
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The largest and most consistent cardiovascular outcome hydrochlorothiazide methyldopa been a reduction in the risk of stroke, but reductions hydrochlorothiazide methyldopa myocardial cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit.A total of 2271 patients hydrochlorothiazide methyldopa moderate to severe hypertension mean baseline systolic/diastolic blood pressure was 170/107 mmHg received treatments of amlodipine/valsartan/hydrochlorothiazide 10 mg/320 mg/25 mg, valsartan/hydrochlorothiazide 320 mg/25 mg, amlodipine/valsartan 10 mg/320 mg, or hydrochlorothiazide/amlodipine 25 mg/10 mg.
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Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated methyldopa hydrochlorothiazide Aug 2020 methyldopa hydrochlorothiazide. eneric Name: Olmesartan, Amlodipine, and Hydrochlorothiazide ole me SAR tan, am LOE di peen, & hye droe klor oh THYE a zide rand Name: Tribenzor Do not take if you are pregnant.hydrochlorothiazide and triamterene may impair your thinking or reactions.
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All strengths are packaged in bottles of 30, 90and 500 tablets.The therapeutic decision will depend on the individual case. rg/about-cancer/cancers-in-general/treatment/cancer-drugs/side-effects/hair-loss-hair-thinning-and-cancer-drugs All Alopecia ContentAlopecia - What is Alopecia?
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Therefore, in these patients blood glucose monitoring should be considered; a dose adjustment of insulin or antidiabetics may be required, when indicated. Latent diabetes mellitus may become manifest during thiazide therapy.Loop methyldopa and hydrochlorothiazide and potassium-sparing agents have minor variable effects. Nonsteroidal anti-inflammatory drugs NSAIDs have also been associated with lithium toxicity, although the relative interactive potential of specific NSAIDs is difficult to determine.
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Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, methyldopa and hydrochlorothiazide consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium.Adverse effects occurring in 2% or more of patients with heart failure receiving valsartan and more frequently than with placebo include dizziness, hypotension, diarrhea, arthralgia, fatigue, back pain, postural dizziness, hyperkalemia, and postural hypotension.
In patients receiving valsartan following acute myocardial infarction, the most common adverse effects resulting in discontinuance of the drug included hypotension, cough, and increased serum methyldopa and hydrochlorothiazide concentration.
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