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Clinical data | |
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Trade names | Apo-hydro, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682571 |
License data | EU EMA: by INN |
Pregnancy category | B (D if used to treat pregnancy-induced hypertension) |
Routes of administration | Oral (capsules, tablets, oral solution) |
ATC code | C03AA03 ( WHO ) |
Legal status | |
Legal status | In general: ℞ (Prescription only) |
Pharmacokinetic data | |
Bioavailability | Variable (~70% on average) |
Metabolism | Not significant [1] |
Elimination half-life | 5.6–14.8 h |
Excretion | Primarily kidney (>95% as unchanged drug) |
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The largest and most consistent cardiovascular outcome hydrochlorothiazide methyldopa been a reduction in the risk of stroke, but reductions hydrochlorothiazide methyldopa myocardial cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit.A total of 2271 patients hydrochlorothiazide methyldopa moderate to severe hypertension mean baseline systolic/diastolic blood pressure was 170/107 mmHg received treatments of amlodipine/valsartan/hydrochlorothiazide 10 mg/320 mg/25 mg, valsartan/hydrochlorothiazide 320 mg/25 mg, amlodipine/valsartan 10 mg/320 mg, or hydrochlorothiazide/amlodipine 25 mg/10 mg.
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Therefore, in these patients blood glucose monitoring should be considered; a dose adjustment of insulin or antidiabetics may be required, when indicated. Latent diabetes mellitus may become manifest during thiazide therapy.Loop methyldopa and hydrochlorothiazide and potassium-sparing agents have minor variable effects. Nonsteroidal anti-inflammatory drugs NSAIDs have also been associated with lithium toxicity, although the relative interactive potential of specific NSAIDs is difficult to determine.
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