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| Clinical data | |
|---|---|
| Pronunciation | / m ɛ t ˈ f ɔːr m ɪ n /, met- FOR -min |
| Trade names | Glucophage, other |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a696005 |
| License data | EU EMA: by INN, US FDA: metformin |
| Pregnancy category | AU: C US: B (No risk in non-human studies) |
| Routes of administration | by mouth |
| ATC code | A10BA02 ( WHO ) |
| Legal status | |
| Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only |
| Pharmacokinetic data | |
| Bioavailability | 50–60% [2] [3] |
| Protein binding | Minimal [2] |
| Metabolism | Not by liver [2] |
| Elimination half-life | 4–8.7 hours [2] |
| Excretion | Urine (90%) [2] |
9 4 e1001204. doi: 0. 371journal. med. MID. Colorado E, Atkinson G, Richter B, Metzendorf MI, Baur L, Station N, Corpeleijn E, O'Malley C, Flushes LJ Reich 2016 "Drug is metformin linked to cancers for the medical of college in men and feet".
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| Tablet name | Metformin |
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After one year, the metformin group scored significantly better on the SRT than the placebo group. The ADAS-Cog, glucose uptake, and plasma Aβ42 did not differ between groups Luchsinger et al.Chaudhari K, Wang J, Xu Y, Winters A, Wang L, Dong X, Cheng EY, Liu R, Yang SH. PLoS One.
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How to get pregnant with metformin?
Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control.
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3 m but that use of the drug should be reviewed when GFR falls below 45 mL/minute per 1.Don't worry about it; you'll be fine.
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Asymptomatic decreases in serum vitamin B12 concentration were reported in about 7-9% of patients receiving metformin alone, and in about 6% of those receiving metformin concomitantly doe metformin prevent cancer a sulfonylurea antidiabetic agent, during 29-week controlled clinical trials.
Such decreases may be related to interference with absorption of vitamin B12 from B12-intrinsic factor complex; however, they rarely are associated with anemia and are rapidly reversible following discontinuation of metformin or supplementation with vitamin B12. Serum folic acid concentrations do not appear to decrease substantially in patients receiving metformin therapy.008-0772.
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Renal clearance is decreased in patients with renal impairment as measured by decreases in creatinine clearance and, apparently because of reduced renal function with age, in geriatric individuals.By January of 2008, I'd gotten my BG under control, and by September my A1c got down to 5.
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