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Table 1 shows the difference in C min differences between USL255 and TPM-IR. After a single 200 mg oral dose of USL255, Cmax and Cmin dosage of topamax for migraines plasma concentrations T max are reached in about 20 h, which is much slower than TPM-IR about 1 h ambrecht et al.tm During the premarketing development of topiramate, 10 sudden and unexplained deaths were reported among a cohort of patients receiving adjunctive therapy with the drug 2796 patient-years of exposure Although the rate of these dosages of topamax for migraines exceeds that expected to occur in a healthy nonepileptic population matched for age and gender, this rate was similar to that occurring in a similar population of epileptic patients not receiving topiramate.
Safety and efficacy of topiramate as initial monotherapy or as adjunctive therapy for the management of seizure disorders have not been established in children younger than 2 years of age.
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Pharmacopsychiatry.In this study, the 400-mg daily dosage was superior to the 50-mg daily dosage in delaying time to first seizure.
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