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Tadalafil
Clinical data
Pronunciation/ t ə ˈ d æ l ə f ɪ l / tə- DAL -ə-fil
Trade namesCialis, Adcirca, Tadacip, others
AHFS/Drugs.comMonograph
MedlinePlusa604008
License dataEU  EMA:  by INN
Pregnancy categoryB
Routes of administrationBy mouth (tablets)
ATC codeG04BE08 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVaries
Protein binding94%
MetabolismLiver (predominantly CYP3A4)
MetabolitesCatechol metabolite
Elimination half-life17.5 hours
ExcretionFeces (~61%), urine (~36%) [1]

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The results demonstrated a difference between the placebo group and the CIALIS group at each of the pre-specified timepoints.

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2007 The impact of lower urinary tract symptoms and comorbidities on quality of life: the BACH and UREPIK studies.The mechanism of Cialis action is based on blocking of phosphodiesterase type 5 enzyme, which affects the smooth muscles of the penis and prevents an erection.

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