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|( R )-(−)-citalopram (top), ( S )-(+)-citalopram (bottom)|
|Pronunciation||/ s aɪ ˈ t æ l ə ˌ p r æ m, s ɪ -/ ; |
|Trade names||Celexa, Cipramil, others (see below)|
|Pregnancy category||US: C (Risk not ruled out)|
|Routes of administration||By mouth|
|Drug class||Selective serotonin reuptake inhibitor (SSRI) |
|ATC code||N06AB04 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only|
|Bioavailability||80% peak at 4 h |
|Metabolism||Liver (CYP3A4 and CYP2C19)|
|Metabolites||Desmethylcitalopram (DCT) and didesmethylcitalopram (DDCT)|
|Elimination half-life||35 h|
|Excretion||Mostly as unmetabolized citalopram, partly DCT and traces of DDCT in urine|
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Increased bleeding e.imilar reactions occur when SSRIs are combined with other drugs that increase serotonin in the brain, for example tryptophan, St. John s wort, meperidine Demerol lithium Lithobid, Eskalith triptans for example, sumatriptanImitrex, Alsuma and tramadol Ultram se of selective serotonin inhibitors may increase the risk of gastrointestinal bleeding in patients taking warfarin Jantoven, Coumadin aspirin, nonsteroidal anti-inflammatory drugs NSAIDs and other drugs that cause bleeding.
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Use the bed only for sleeping and sexual activity.Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers. ONITOR: erotonin reuptake inhibitors SRIs may potentiate the risk of bleeding in patients treated with ulcerogenic agents and agents that affect hemostasis such as anticoagulants, platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia.
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J Neural Transm Gen Sect Noradrenaline and dopamine efflux in the prefrontal cortex in relation to appetitive classical conditioning. J Neurosci Stress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats.pentamidine, levomethadyl populations.
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